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Cell Rep:厦大外籍教授发表代谢调控机制研究论文

摘要 : 近日,国际著名学术杂志《Cell》子刊《Cell Reports》杂志在线发表了厦门大学药学院Dieter Wolf教授课题组题为“A transcript-specific eIF3 complex mediates global translational control of energy metabolism”的文章

 近日,国际著名学术杂志《Cell》子刊《Cell Reports》杂志在线发表了厦门大学药学院Dieter Wolf教授课题组题为“A transcript-specific eIF3 complex mediates global translational control of energy metabolism”的文章,课题组硕士研究生苏丹为共同第一作者 。

研究利用转录组学、蛋白组学和代谢组学的方法发现缺少了eIF3e和eIF3d的裂殖酵母细胞无法合成线粒体电子传递链相关的蛋白,从而导致呼吸功能阻断,内源性的氧化应激压力和细胞老化产生。 酵母细胞通过提高葡萄糖合成酶和糖酵解作用维持能量代谢的平衡。在人体细胞中我们也发现了同样的代谢调节途径,主要通过eIF3e蛋白与代谢相关的mRNA结合并促进这些与能量代谢相关的蛋白表达来维持代谢的平衡。在肿瘤形成的过程中,这种通过eIF3d和eIF3e调控的能量代谢机制是被打破的,因此该研究成果将有助于科学家通过靶向代谢通路研发治愈肿瘤的药物。

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原文链接:

A Transcript-Specific eIF3 Complex Mediates Global Translational Control of Energy metabolism

原文摘要:

The multi-subunit eukaryotic translation initiation factor eIF3 is thought to assist in the recruitment of ribosomes to mRNA. The expression of eIF3 subunits is frequently disrupted in human cancers, but the specific roles of individual subunits in mRNA translation and cancer remain elusive. Using global transcriptomic, proteomic, and metabolomic profiling, we found a striking failure of Schizosaccharomyces pombe cells lacking eIF3e and eIF3d to synthesize components of the mitochondrial electron transport chain, leading to a defect in respiration, endogenous oxidative stress, and premature aging. Energy balance was maintained, however, by a switch to glycolysis with increased glucose uptake, upregulation of glycolytic enzymes, and strict dependence on a fermentable carbon source. This metabolic regulatory function appears to be conserved in human cells wher eIF3e binds metabolic mRNAs and promotes their translation. Thus, via its eIF3d-eIF3e module, eIF3 orchestrates an mRNA-specific translational mechanism controlling energy metabolism that may be disrupted in cancer.

来源: Cell Reports 浏览次数:0

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