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标签:PGCs DNA甲基化
摘要 : 来自北京大学的研究人员报告称,他们首次绘制出了人类原始生殖细胞(PGCs)的转录组及DNA甲基化组图谱。这一重要的研究成果发布在6月4日的《细胞》(Cell)杂志上。






原文标题:The Transcriptome and DNA Methylome Landscapes of Human Primordial Germ Cells

原文摘要:Germ cells are vital for transmitting genetic information from one generation to the next and for maintaining the continuation of species. Here, we analyze the transcriptome of human primordial germ cells (PGCs) from the migrating stage to the gonadal stage at single-cell and single-base resolutions. Human PGCs show unique transcription patterns involving the simultaneous expression of both pluripotency genes and germline-specific genes, with a subset of them displaying developmental-stage-specific features. Furthermore, we analyze the DNA methylome of human PGCs and find global demethylation of their genomes. Approximately 10 to 11 weeks after gestation, the PGCs are nearly devoid of any DNA methylation, with only 7.8% and 6.0% of the median methylation levels in male and female PGCs, respectively. Our work paves the way toward deciphering the complex epigenetic reprogramming of the germline with the aim of restoring totipotency in fertilized oocytes.

来源: Cell 浏览次数:0


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