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Curr Biol:英国学者揭示延迟用餐有助调整生物钟

摘要 : 2017年6月1日,国际著名学术杂志《Cell》子刊《Current Biology》杂志在线发表了英国萨里大学Jonathan D. Johnston研究员的一篇研究论文,研究报告称一种调节生物钟的简单方法。

2017年6月1日,国际著名学术杂志《Cell》子刊《Current Biology》杂志在线发表了英国萨里大学Jonathan D. Johnston研究员的一篇研究论文,研究报告称一种调节生物钟的简单方法。研究人员表示,倒时差其实很简单,只需改变吃饭时间就可以,这样做能够改变体内血糖水平波动周期,从而调整生物钟。结果显示有规律的用餐时间或许能帮助人们保持生物钟。

人体机能的运行会参照一个24小时生物钟,该时钟由人脑和外部环境所控制。研究“用餐时间延迟5小时,也能导致血糖水平变化推迟5小时。”Jonathan Johnston说,“我们认为这归因于人体内新陈代谢组织时钟的变化,而非人脑中的主时钟。”


研究中Johnston、Sophie Wehrens及其同事,征募了10名志愿者,向他们提供一日三餐。第一阶段,早餐时间在醒来后30分钟,间隔5小时上中餐,再过5小时吃晚餐。第二阶段中,早餐在志愿者醒来后5小时才开动,中餐仍在早餐后5小时,再隔5小时是晚餐。每个阶段结束后,研究人员立即采集志愿者的血液和脂肪样本,以了解他们的生理节律。



Meal Timing Regulates the Human Circadian System


Circadian rhythms, metabolism, and nutrition are intimately linked [1, 2], although effects of meal timing on the human circadian system are poorly understood. We investigated the effect of a 5-hr delay in meals on markers of the human master clock and multiple peripheral circadian rhythms. Ten healthy young men undertook a 13-day laboratory protocol. Three meals (breakfast, lunch, dinner) were given at 5-hr intervals, beginning either 0.5 (early) or 5.5 (late) hr after wake. Participants were acclimated to early meals and then switched to late meals for 6 days. After each meal schedule, participants’ circadian rhythms were measured in a 37-hr constant routine that removes sleep and environmental rhythms while replacing meals with hourly isocaloric snacks. Meal timing did not alter actigraphic sleep parameters before circadian rhythm measurement. In constant routines, meal timing did not affect rhythms of subjective hunger and sleepiness, master clock markers (plasma melatonin and cortisol), plasma triglycerides, or clock gene expression in whole blood. Following late meals, however, plasma glucose rhythms were delayed by 5.69 ± 1.29 hr (p < 0.001), and average glucose concentration decreased by 0.27 ± 0.05 mM (p < 0.001). In adipose tissue, PER2 mRNA rhythms were delayed by 0.97 ± 0.29 hr (p < 0.01), indicating that human molecular clocks may be regulated by feeding time and could underpin plasma glucose changes. Timed meals therefore play a role in synchronizing peripheral circadian rhythms in humans and may have particular relevance for patients with circadian rhythm disorders, shift workers, and transmeridian travelers.

来源: Current Biology 浏览次数:0


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