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Curr Biol:北京大学谢灿实验室初步揭示章鱼动态变色的起源和原理

摘要 : 2017年9月7日,国际著名学术杂志《Cell》子刊《Current Biology》杂志在线发表了北京大学生命科学学院谢灿实验题为室“Origin of the reflectin gene and hierarchical assembly of its protein”的研究成果

2017年9月7日,国际著名学术杂志《Cell》子刊《Current Biology》杂志在线发表了北京大学生命科学学院谢灿实验题为室“Origin of the reflectin gene and hierarchical assembly of its protein”的研究成果,并被选为该杂志的封面文章。博士生管哲以及蔡甜甜为共同第一作者,谢灿为通讯作者。

在自然界中,头足类动物(章鱼、墨鱼、鱿鱼)以动态变色和拟态隐形而著称。它们能够根据环境的变化快速调节体色、皮肤纹理和外貌特征,从而达到伪装掩饰、信息交流或者是警戒恐吓的目的。Reflectin蛋白家族是其结构变色的物质基础,但只存在于有着“外星生物”之称的头足类动物中,其基因起源和作用机理不明。北京大学生命科学学院谢灿课题组及其合作者历经五年的探索,将该基因的起源追溯到一种和海洋生物(包括头足类动物)共生的细菌转座子基因片段上,并据此提出了reflectin基因起源于共生细菌的水平基因转移假说。同时也报道了Reflectin蛋白质的电镜结构,发现该蛋白在一些化学分子和神经递质的刺激下能快速组装成各种各样的片层结构,和先前文献报道的该类动物皮肤细胞中出现的反射器结构类似,初步揭示了reflectin介导的动态结构色彩的分子机理。同时还发现所有这些独特的组装性质均可追溯至前述细菌转座子基因编码的八个氨基酸序列,因此将这八个氨基酸称之为“原肽(Protopeptide)”。

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图示头足类动物结构变色中起关键作用的reflectin的基因起源,及reflectin蛋白质的分级组装构成了头足类动物动态结构色彩的基础

原文链接:

Origin of the Reflectin Gene and Hierarchical Assembly of Its Protein

原文摘要:

Cephalopods, the group of animals including octopus, squid, and cuttlefish, have remarkable ability to instantly modulate body coloration and patterns so as to blend into surrounding environments [ 1, 2 ] or send warning signals to other animals [ 3 ]. Reflectin is expressed exclusively in cephalopods, filling the lamellae of intracellular Bragg reflectors that exhibit dynamic iridescence and structural color change [ 4 ]. Here, we trace the possible origin of the reflectin gene back to a transposon from the symbiotic bioluminescent bacterium Vibrio fischeri and report the hierarchical structural architecture of reflectin protein. Intrinsic self-assembly, and higher-order assembly tightly modulated by aromatic compounds, provide insights into the formation of multilayer reflectors in iridophores and spherical microparticles in leucophores and may form the basis of structural color change in cephalopods. Self-assembly and higher-order assembly in reflectin originated from a core repeating octapeptide (here named protopeptide), which may be from the same symbiotic bacteria. The origin of the reflectin gene and assembly features of reflectin protein are of considerable biological interest. The hierarchical structural architecture of reflectin and its domain and protopeptide not only provide insights for bioinspired photonic materials but also serve as unique “assembly tags” and feasible molecular platforms in biotechnology.

来源: Current Biology 浏览次数:0

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