The Relationship Between High Uric Acid and Kidneys 💧 The efficiency of the kidneys' glomeruli filters can decrease due to high uric acid levels. Excessive uric acid in the blood can crystallize and deposit in the kidneys, potentially leading to decreased kidney function or even kidney stones and other serious health issues. Therefore, maintaining normal uric acid levels is crucial for protecting kidney health. Adjusting your diet (such as reducing intake of high-purine foods), drinking plenty of water, and using medication when necessary can help manage uric acid levels. Regular check-ups and monitoring of uric acid and kidney function indicators can help detect and address potential issues early on.